MCC950 SODIUM SALT (CP-456773)
N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide monosodium salt
CAS: 256373-96-3
Molecular Formula: C20H23N2NaO5S
MCC950 SODIUM SALT (CP-456773) - Names and Identifiers
MCC950 SODIUM SALT (CP-456773) - Physico-chemical Properties
| Molecular Formula | C20H23N2NaO5S |
| Molar Mass | 426.46179 |
| Solubility | H2O: ≥ 30 mg/mL |
| Appearance | powder |
| Color | white to beige |
| Storage Condition | room temp |
| In vitro study | MCC950 inhibits classical and non-classical NLRP3 activation with IC50 of 7.5 and 8.1 nM in bone marrow-derived macrophages and human monocyte-derived macrophages, respectively. MCC950 specifically inhibits the activation of NLRP3 and does not inhibit AIM2, NLRC4 or NLRP1 These inflammasomes. |
| In vivo study | MCC950 reduces interleukin-1β (IL-1β) production and reduces the severity of experimental autoimmune encephalomyelitis. In a mouse model of the autoinflammatory disease Cryopyrin-associated cyclic syndrome, MCC950 was able to rescue neonatal death. In indirect in vitro experiments, it was active in samples derived from patients with Veyer's syndrome. |
MCC950 SODIUM SALT (CP-456773) - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.345 ml | 11.724 ml | 23.449 ml |
| 5 mM | 0.469 ml | 2.345 ml | 4.69 ml |
| 10 mM | 0.234 ml | 1.172 ml | 2.345 ml |
| 5 mM | 0.047 ml | 0.234 ml | 0.469 ml |
Last Update：2024-01-02 23:10:35
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View History
MCC950 SODIUM SALT (CP-456773)
2-Chloromethyl-4-(3-methoxypropoxy)-3-methylpyridin
甲基丙烯酸3-磺酸丙酯钾盐
boc-d-3-氨基-3-(3-溴苯基)丙酸
2-((1-CYANOETHYL)AMINO)BENZOIC ACID
化合物MITOSOX RED
4-甲基伞形基-Β-D-吡喃葡糖苷
1-Cyano-cyclohexanecarboxylic acid ethyl ester
Methyl 3-aMino-4-((tert-butoxycarbonyl)aMino)benzoate
Topiroxostat Impurity 21
2-Chloromethyl-4-(3-methoxypropoxy)-3-methylpyridin
甲基丙烯酸3-磺酸丙酯钾盐
boc-d-3-氨基-3-(3-溴苯基)丙酸
2-((1-CYANOETHYL)AMINO)BENZOIC ACID
化合物MITOSOX RED
4-甲基伞形基-Β-D-吡喃葡糖苷
1-Cyano-cyclohexanecarboxylic acid ethyl ester
Methyl 3-aMino-4-((tert-butoxycarbonyl)aMino)benzoate
Topiroxostat Impurity 21